About COMIRNATY,
a Pfizer and BioNTech
COVID-19 vaccine for people 
12 years of age & older, and
how it works

Older adult male and young woman hugging
COMIRNATY is a vaccine for use in people 12 years of age and older to protect against coronavirus disease 2019 (COVID-19).

The CDC’s recommendation includes that people 12 years of age and older should receive a 2024-2025 COVID-19 vaccine.

If you are 65 years of age or older, or have a weakened immune system, talk to your healthcare provider or visit CDC.gov to learn more about when you may be CDC-recommended to receive an additional dose.

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About Updated COMIRNATY

How COMIRNATY Works

COVID-19 Vaccine Costs

About Updated COMIRNATY

Actor portrayal of doctor discussing with her patient
Over time, the virus that causes COVID-19 can evolve and protection from previous vaccination can decline. This can leave you at increased risk for COVID-19 and serious illness. Getting vaccinated with the 2024-2025 Formula of COMIRNATY can help protect against COVID-19.
The formula of COMIRNATY was updated following the FDA's recommendation that COVID-19 vaccines should be updated to help protect against circulating strains of the virus that causes COVID-19. The 2024-2025 Formula of COMIRNATY is made using a process similar to previous formulas, with the difference only in the mRNA which encodes the viral spike protein.

The current formula of COMIRNATY is an updated vaccine and not a booster dose of a vaccine. There's a difference between an updated vaccine and a booster dose of a vaccine. An updated vaccine contains an updated formula that is anticipated to help protect against circulating strains of the virus that causes COVID-19. A booster dose of a vaccine is an additional dose of the vaccine previously received.

Learn more about the differences between updated vaccines and boosters

How COMIRNATY Works

COMIRNATY helps train your immune system.

After vaccination, it works to help your body recognize and fight the virus that causes COVID-19 without you ever having been exposed to it.

COMIRNATY is composed of mRNA wrapped in a protective coating for delivery. After vaccination, the mRNA enters the cell.

Illustration of how COMIRNATY works

mRNA provides the cell instructions to build copies of spike protein found on the surface of the virus that causes COVID-19.

Illustration of how COMIRNATY works

The spike protein is presented on the surface of the cell and trains the immune system. The resulting immune response, which includes antibodies, is what recognizes and helps fight COVID-19 if you are exposed to the virus in the future.

Illustration of how COMIRNATY works

mRNA technology, used by mRNA COVID-19 vaccines including COMIRNATY, has the potential to streamline vaccine development. This allows for a timely response to FDA-recommended updates to the vaccine for emerging strains of the virus that causes COVID-19.
COMIRNATY does not contain SARS-CoV-2, the virus that causes COVID-19. COMIRNATY cannot give you COVID-19.
These illustrations are intended for educational purposes only.

COVID-19 Vaccine Costs

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Most people with insurance should continue to pay $0 out of pocket for COVID-19 vaccines by Pfizer & BioNTech, including COMIRNATY.

If you don’t have health insurance or cannot afford out-of-pocket costs, please read the information below.

Pfizer’s Patient Assistance Programs

Eligible* people 12 years of age and older without insurance can receive COMIRNATY at no cost:

  1. At participating retail pharmacies by applying through the Pfizer Retail Vax Assistance Program
  2. Through select federally qualified health centers, hospitals, and free clinics participating in Pfizer’s Institutional Patient Assistance Program (IPAP)

Please check PfizerRxPathways.com for the latest information.

*Eligible patients cannot have prescription or medical insurance; age and other eligibility restrictions apply.

IMPORTANT: Always call the vaccination location to ensure they have COMIRNATY in stock prior to visiting.

Vaccines for Children Program

If you do not have insurance or are enrolled in Medicaid, the Vaccines for Children (VFC) Program may be able to help. The VFC is a government-funded program that provides vaccines at no cost to children 19 years of age and younger who might not otherwise be vaccinated because they are not able to pay. The vaccines are given for free, but there might be other costs, such as payment for the visit or other services.


Learn more about the VFC Program and eligibility here.

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Learn More About COVID-19

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